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Laboratory findingsWhen laboratory mice are exposed to artificial sunlightthey often develop skin tumorsThese sunlight-induced tumors may appear more quickly and in greater number if the mouse is also topically treated with the active ingredient in RETIN-AtretinoinIn some studiesunder different conditionshoweverwhen mice treated with tretinoin were exposed to artificial sunlightthe incidence and rate of development of skin tumors was reducedThere is no evidence to date that tretinoin alone will cause the development of skin tumors in either laboratory animals or humansHoweverinvestigations in this area are continuing.

To help you use the medication correctlykeep these simple instructions in mind.

Store at room temperature away from light and moistureGel preparations are flammableDo not expose to heat or fire sourcesDo not smoke during useKeep all medications away from children and pets.

The skin of certain sensitive individuals may become excessively rededematousblisteredor crustedIf these effects occurthe medication should either be discontinued until the integrity of the skin is restoredor the medication should be adjusted to a level the patient can tolerateTrue contact allergy to topical tretinoin is rarely encounteredTemporary hyperor hypopigmentation has been reported with repeated application of RETIN-ASome individuals have been reported to have heightened susceptibility to sunlight while under treatment with RETIN-ATo dateall adverse effects of RETIN-A have been reversible upon discontinuance of therapysee DOSAGE AND ADMINISTRATION Section

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