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Flushingsweatingvaginal dryness and irritation and reduction in breast sizemay reflect lowering of estrogenNervousness and emotional lability have been reportedIn the male a modest reduction in spermatogenesis may be evident during treatmentAbnormalities in semen volumeviscositysperm countand motility may occur in patients receiving long-term therapy.
Before initiating therapy of fibrocystic breast disease with Danazolcarcinoma of the breast should be excludedHowevernodularitypaintenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begunThereforeif any nodule persists or enlarges during treatmentcarcinoma should be considered and ruled out.
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
An overdose of danazol is not expected to produce life threatening symptomsHoweverlong term use of high doses can lead to symptoms such as weight gainincreased acne or facial hairmenstrual problemsor breast changes.
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