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Grapefruit juicecranberry juicenoni juiceand pomegranate juice may interact with warfarin and lead to unwanted side effectsAvoid the use of these juice products while taking Coumadin.

Prophylaxis and treatment of venous thrombosis and its extensionpulmonary embolismPEProphylaxis and treatment of thromboembolic complications associated with atrial fibrillationAFand/or cardiac valve replacementReduction in the risk of deathrecurrentmyocardial infarctionMIand thromboembolic events such as stroke or systemic embolization after myocardial infarction.

COUMADIN is contraindicated in women who are pregnant except in pregnant women with mechanical heart valveswho are at high risk of thromboembolismsee WARNINGS AND PRECAUTIONS and Use In Specific PopulationsCOUMADIN can cause fetal harm when administered to a pregnant womanCOUMADIN exposure during pregnancy causes a recognized pattern of major congenital malformationswarfarin embryopathy and fetotoxicityfatal fetal hemorrhageand an increased risk of spontaneous abortion and fetal mortalityIf COUMADIN is used during pregnancy or if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to a fetussee Use In Specific Populations

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