Generic for estrace can cause side effects such as breast pain, changes in sex drive, breakthrough bleeding, depression, fatigue, vaginal discharge, and abdominal pain.

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ESTRACE vaginal cream should be used at the lowest dose possible for your treatment only as long as neededAlthough ESTRACE vaginal cream is only used in and around the vaginathe risks associated with oral estrogens should be taken into account.

Use of ESTRACE alone or in combination with a progestinshould be limited to the shortest duration consistent with treatment goals and risks for the individual womanPostmenopausal women should reevaluate periodically as clinically appropriate to determine if treatment is still necessaryFor treatment of vulvar and vaginal atrophy associated with the menopausethe lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possibleFor women who have a uterusadequate diagnostic measuresincluding directed and random endometrial sampling when indicatedshould be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal genital bleeding.

The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.

Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milkDetectable amounts of estrogens have been identified in the milk of mothers receiving this drugCaution should be exercised when Estrace is administered to a nursing woman.

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it may be noted that drugs other than those listed above may also interact with generic for estrace .

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