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Carbidopa reduces the amount of levodopa required to produce a given response by about 75andwhen administered with levodopaincreases both plasma levels and the plasma half-life of levodopaand decreases plasma and urinary dopamine and homovanillic acid.

Management of acute overdosage with SINEMET is the same as management of acute overdosage with levodopaPyridoxine is not effective in reversing the actions of SINEMET.

Ataxiaextrapyramidal disorderfallinganxietygait abnormalitiesnervousnessdecreased mental acuitymemory impairmentdisorientationeuphoriablepharospasmwhich may be taken as an early sign of excess dosageconsideration of dosage reduction may be made at this timetrismusincreased tremornumbnessmuscle twitchingactivation of latent Horner’s syndromeperipheral neuropathy.

Carbidopa reduces the amount of levodopa required to produce a given response by about 75andwhen administered with levodopaincreases both plasma levels and the plasma half-life of levodopaand decreases plasma and urinary dopamine and homovanillic acid.

If you have any concerns about taking this medicineask your doctor or pharmacist.

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