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There have been reports of increases and decreases in blood glucose levels in patients treated with fluoroquinolone type antibioticsfor examplelevofloxacinLevaquinand ciprofloxacinCipro
All medicines may cause side effectsbut many people have noor minorside effectsCheck with your doctor if any of these most COMMON side effects persist or become bothersome:
Elderly patients are particularly susceptible to the hypoglycemic action of glucose lowering drugsHypoglycemia may be difficult to recognize in the elderlysee PRECAUTIONSThe initial and maintenance dosing should be conservative to avoid hypoglycemic reactionssee DOSAGE AND ADMINISTRATION
Sulfonylurea drugs are extensively bound to serum proteinsDisplacement from protein binding sites by other drugs may lead to enhanced hypoglycemic actionIn vitrothe protein binding exhibited by glyburide is predominantly non-ionicwhereas that of other sulfonylureaschlorpropamidetolbutamidetolazamideis predominantly ionicAcidic drugs such as phenylbutazonewarfarinand salicylates displace the ionic-binding sulfonylureas from serum proteins to a far greater extent than the non-ionic binding glyburideIt has not been shown that this difference in protein binding will result in fewer drug-drug interactions with MICRONASE Tablets in clinical use.
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