Glucarpidase is indicated for the treatment of toxic methotrexate concentrations in patients with delayed methotrexate clearance due to impaired renal function; do not administer leucovorin within 2 hours before or after a dose of glucarpidase because leucovorin is a substrate for glucarpidase.

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Tell your doctor right away if you have any serious side effectsincludingmouth soresdiarrheasigns of anemiasuch as unusual tirednesspale skinsigns of liver problemssuch as dark urinepersistent nausea/vomitingstomach/abdominal painyellowing eyes/skineasy bruising/bleedingblack stoolsenlarged glands/lymph nodesbone painunusual pain and discoloration of the skinsigns of kidney problemssuch as change in the amount of urinedry coughmuscle weakness.

Methotrexate should NOT be taken if you are pregnant or planning to get pregnant or breast-feedingMethotrexate may be temporarily discontinued if you are having surgeryincluding dental surgeryInform your surgeon or dentist about the medication prior to the surgeryMethotrexate sensitises your skin to sunlightAvoid unnecessary or prolonged sun exposure and wear protective gearIf you have psoriasisyour sores may worsen if you expose your skin to sunlight while you are taking methotrexateVaccinationsespecially live onesare not to be given while you are taking methotrexateDiscuss this with your doctor for safer options.

Methotrexate is a prescription medicationIt comes in four formsself-injectable solutioninjectable IV solutionoral tabletand oral solution.

Generic Namemethotrexateoralmeth oh TREX ateBrand NamesRheumatrex Dose PackTrexallXatmep.

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the active metabolite is further metabolized and ex- to the deposition of methotrexate and its metabolites in creted through the kidneys and biliary tract.

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