Important facts about colchicine for gout.
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Prophylaxis of gout attack during initiation of therapy with allopurinol and uricosuric drugs:
Colchicine is a substrate of the efflux transporter P-glycoproteinP-gpand the CYP3A4 metabolizing enzymeFatal drug interactions have been reported when colchicine is administered with clarithromycina dual inhibitor of CYP3A4 and P-glycoproteinToxicities have also been reported when colchicine is administered with inhibitors of CYP3A4 that may not be potent inhibitors of P-gpe.ggrapefruit juiceerythromycinverapamilor inhibitors of P-gp that may not be potent inhibitors of CYP3A4e.gcyclosporine
A 4-fold reduction in colchicine dosage is recommended when co-administered with a P-gp inhibitor and/or a strong CYP3A4 inhibitorA 2-fold reduction in colchicine dosage is recommended when co-administered with a moderate CYP3A4 inhibitor.
Colchicine comes as a tablet to take by mouth with or without foodWhen colchicine is used to prevent gout attacks or to treat FMFit is usually taken once or twice a dayWhen colchicine is used to relieve the pain of a gout attackone dose is usually taken at the first sign of pain and a secondsmaller dose is usually taken one hour laterIf you do not experience relief or have another attack within several days after treatmenttalk to your doctor before taking additional doses of medicationFollow the directions on your prescription label carefullyand ask your doctor or pharmacist to explain any part you do not understandTake colchicine exactly as directedDo not take more or less of it or take it more often than prescribed by your doctor.
Colchicine capsules are not an analgesic medication and should not be used to treat pain from other causes.
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colchicine crosses the placenta and distributes into breast milk see pregnancy and nursing mothers .