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As a consequence of a recent European regulatory initiativethe Clozaril Summary of Product CharacteristicsSmPChas been harmonised across EuropeThe SmPC states that blood monitoring should be carried out in accordance with national-specific official recommendationsThese are reproduced below.
Do not stop taking clozapine without consulting your doctorSome conditions may become worse when the drug is suddenly stoppedAlsoyou may experience symptoms such as severe sweatingheadachenauseavomitingand diarrheaTo prevent these symptoms while you are stopping treatment with this drugyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsReport any new or worsening symptoms right away.
Patients who have low WBC counts because of benign ethnic neutropenia should be given special consideration and may only be started on Clozaril with the agreement of a haematologist.
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