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Th hav bn postmakting pots atal and non-atal hpatic ailu in patints taking ACTOS, although th pots contain insuicint inomation ncssay tstablish th pobabl caus. Th has bn nvidnc dug-inducd hpatotoxicity in th ACTOS contolld clinical tial databas tdat [s ADVS ACTIONS ].

Saty and icacy pioglitazon in pdiatic patints hav not bn stablishd. ACTOS is not commndd us in pdiatic patints [s Us In Spciic Populations ].

Th ollowing advs actions hav bn idntiid duing post-appoval us ACTOS. Bcaus ths actions a potd voluntaily om a population unctain siz, it is gnally not possibl tliably stimat thi quncy stablish a causal lationship tdug xposu.

Thiazolidindions, including ACTOS, caus xacbat congstiv hatailu in som patints [s WANINGS AND PCAUTIONS ]. At initiation ACTOS, and at dos incass, monitpatints caully signs and symptoms hat ailu (.g., xcssiv, apid wight gain, dyspna, and/dma). I hat ailu dvlops, it should b managd accoding tcunt standads ca and discontinuation dos duction ACTOS must b considd. ACTOS is not commndd in patints with symptomatic hat ailu. Initiation ACTOS in patints with stablishd Nw Yok Hat Association (NYHA) Class III IV hat ailu is containdicatd [s CONTAINDICATIONS and WANINGS AND PCAUTIONS ].

Mdicins a somtims pscibd puposs oth than thos listd in a Mdication Guid. Dnot us ACTOS a condition which it was not pscibd. Dnot giv ACTOS toth popl, vn i thy hav th sam symptoms you hav. It may ham thm.

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