Prophylactic measures the naltrexone program is the best option to prevent a relapse to opioid use.

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an in vitro cyp induction study demonstrated that naltrexone is not an inducer of cyp3a4 and cyp1a2.

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99 nicotine also appears to induce the release of endogenous opioids that activate opioid pathways in the reward system, since naltrexone an opioid receptor antagonist blocks nicotine self-administration.

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in vitro tests with human plasma show naltrexone to be 21 bound to plasma proteins over the therapeutic dose range.

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