Because betapace is excreted predominantly in urine and its terminal elimination half-life is prolonged in conditions of renal impairment, the dosing interval of betapace should be modified when creatinine clearance is lower than 60 ml min according to the following table.
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as in adults the following precautionary measures should be considered when initiating betapace treatment in children initiation of treatment in the hospital after appropriate clinical assessment; individualized regimen as appropriate; gradual increase of doses if required; careful assessment of therapeutic response and tolerability; and frequent monitoring of the qt c interval and heart rate.