In a study conducted in healthy subjects, mean steady-state lithium plasma levels increased approximately 17 in subjects receiving lithium 450 mg twice daily with celebrex 200 mg twice daily as compared to subjects receiving lithium alone see drug interactions 7 .
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at the end of 2004, the fda issued a public health advisory summarizing the agency s recent recommendations concerning the use of the nonsteroidal anti-inflammatory drug products nsaids vioxx, bextra, celebrex, and naproxen.
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avoid the use of celebrex in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal function.
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