Amantadine and metabolites are inhibitors of phosphodiesterase iii; such activity has been shown to decrease survival of patients with class iii-iv congestive heart failure chf ; contraindicated in patients with chf of any severity this medication contains amantadine.
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rare instances of reversible elevation of liver enzymes have been reported in patients receiving amantadine hydrochloride, though a specific relationship between the drug and such changes has not been established.
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