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the resulting white suspension was centrifuged at room temperature 14000 rpm, 10 min , the supernatant liquid was discarded and the resulting solid was dried at vacuum to provide 17 mg of co-crystal rosuvastatin pyrazine hydrate as a white solid for a molar yield of 50 .

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during this period, the rosuvastatintreated rats showed significant increases in the number of circulating epcs.

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19 although rosuvastatin lowered plasma lipid concentrations to a greater extent than atorvastatin, the study reported that atorvastatin seems to have more renoprotective effects.

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therefore, in patients taking cyclosporine, the dose of rosuvastatin should not exceed 5 mg once daily see dosage and administration 2.


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