The research, which appears today in the new england journal of medicine, is the third recent study to raise questions about the effectiveness of zetia and vytorin, highly profitable medications by merck.

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when the fda approved zetia in 2002 it relied on trials that covered only 3,900 patients and lasted no more than 12 weeks.

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reductions in sitosterol and campesterol were consistent between patients taking zetia concomitantly with bile acid sequestrants n 8 and patients not on concomitant bile acid sequestrant therapy n 21 .


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