Use in patients with electrolyte disorders in patients with hypokalemia or hypomagnesemia, toxicity may occur despite serum digoxin concentrations below 2 ng ml, because potassium or magnesium depletion sensitizes the myocardium to digoxin.
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the recent study that found digoxin increases mortality used an approach called time-varying treatment, where patients who continued to receive digoxin over 3.
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