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lorazepam administration of intramuscular lorazepam 2 mg 1 hour after intramuscular olanzapine for injection 5 mg did not significantly affect the pharmacokinetics of olanzapine, unconjugated lorazepam, or total lorazepam.
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in clinical trials of oral olanzapine monotherapy for the treatment of schizophrenia in adult patients, treatment-emergent adverse reactions with an incidence of 5 or greater in the olanzapine treatment arm and at least twice that of placebo were postural hypotension, constipation, weight gain, dizziness, personality disorder, and akathisia.
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make dosage adjustments, if indicated, according to efficacy and tolerability within dose ranges of fluoxetine 20 to 50 mg and oral olanzapine 5 to 12.
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patients may develop severe sedation, coma, and or delirium after an injection of extended release olanzapine.
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