The pharmacokinetics of pristiq are unlikely to be affected by drugs that inhibit the p glycoprotein transporter, and desvenlafaxine is not likely to affect the pharmacokinetics of drugs that are substrates of the p-glycoprotein transporter.

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pristiq failed to outperform placebo in either of the two trials, while effexor xr beat placebo in the study in which it was dosed at 206 mg day it did not separate from placebo when its average dose was 118 mg day .

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