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by using a racemic mixture of promethazine for in vivo injection, we demonstrated that promethazine accumulates and is retained briefly in normal brains before being almost completely washed out after 240 min.
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promethazine hydrochloride tablets are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
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promethazine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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