Our inclusion criteria were as follows i any study type that reported patient outcomes except single case reports; ii for clinical studies, only children under 12 years of age, and for pharmacokinetic studies, adults as well; iii as antibiotics, amoxicillin, ampicillin, cotrimoxazole, gentamicin, penicillin g, chloramphenicol, ceftriaxone and ciprofloxacin; as a control in controlled trials, placebo or active treatment; as predefined outcomes, death, recovery, weight gain, prevention of septic shock and adverse events.

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angiotensin-converting enzyme ace inhibitors, such as benazepril lotensin , captopril capoten , enalapril vasotec , fosinopril monopril , lisinopril prinivil, zestril , moexipril univasc , perindopril, aceon , quinapril accupril , ramipril altace , and trandolapril mavik antibiotics known as quinolone or fluoroquinolone, such as cinoxacin cinobac , ciprofloxacin cipro , enoxacin penetrex , gatifloxacin tequin , levofloxacin levaquin , lomefloxacin maxaquin , moxifloxacin avelox , nalidixic acid neggram , norfloxacin noroxin , ofloxacin floxin , sparfloxacin zagam , or trovafloxacin and alatrofloxacin combination trovan aspirin and other nonsteroidal anti-inflammatory medications nsaids , such as ibuprofen advil, motrin and naproxen aleve, naprosyn asthma drugs blood thinners, such as warfarin coumadin beta blockers, such as atenolol tenormin , labetalol normodyne , metoprolol lopressor, toprol xl , nadolol corgard , and propranolol inderal bosentan tracleer , for high blood pressure in the lungs pulmonary hypertension calcium channel blockers, such as amlodipine norvasc , diltiazem cardizem, dilacor, tiazac, others , felodipine plendil , isradipine dynacirc , nicardipine cardene , nifedipine adalat, procardia , nimodipine nimotop , nisoldipine sular , and verapamil calan, isoptin, verelan chloramphenicol, an antibiotic clarithromycin biaxin , an antibiotic cold medicines contraceptives, such as birth control pills, patches, rings, implants, and injections cyclosporine neoral, sandimmune , an immunosuppressant diabetes and blood-sugar drugs, such as insulin and others disopyramide norpace , a heart drug fluconazole diflucan , for fungal infections hormone replacement therapy isoniazid inh maois, such as isocarboxazid marplan , phenelzine nardil , selegiline eldepryl, emsam, zelapar , and tranylcypromine parnate mental illness medications, such as fluoxetine prozac, sarafem and others miconazole monistat , for yeast infections nausea medicine niacin, a type of vitamin b used for many conditions oral steroids such as dexamethasone decadron, dexone , methylprednisolone medrol , and prednisone deltasone phenytoin dilantin , a seizure medicine probenecid benemid , for preventing gout or to treat some types of arthritis rifampin, an antibiotic for tuberculosis salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate arthropan , diflunisal dolobid , magnesium salicylate doan s, others , and salsalate argesic, disalcid, salgesic sulfa drugs, including antibiotics, such as co-trimoxazole bactrim, septra ; and the arthritis drug sulfasalazine azulfidine thyroid medications water pills diuretics .

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