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In some tamoxifen adjuvant trials in women who are axillary node positive, most of the benefit has been in the subgroup with 4 positive axillary lymph nodes.
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A according to the package insert, tamoxifen citrate nolvadex does not have elevated blood sugar as a side effect that was reported during clinical trials or that has been reported after the drug was put to market.
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paik s, shak s, tang g, et al expression of the 21 genes in the recurrence score assay and prediction of clinical benefit from tamoxifen in nsabp study b-14 and chemotherapy in nsabp study b-20 abstract 24 .