Concomitant administration of propranolol and amaryl significantly increased glimepiride cmax, auc, and t by 23 , 22 , and 15 , respectively, and decreased glimepiride cl f by 18 .

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the metabolism of propranolol is reduced by co-administration of quinidine, leading to a two-three fold increased blood concentration and greater degrees of clinical beta-blockade.

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this result would be compatible with the regression observed in ih, and it would suggest that propranolol could delay the proliferation of hemangioblastomas in vhl patients.

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if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart problems eg, heart failure , abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems eg, paralysis, blockage , adrenal or pituitary problems, eye or vision problems eg, macular degeneration , bladder cancer, or lactic acidosis if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin b 12 levels, or anemia, or if you are dehydrated if you have an infection, fever, recent injury, or moderate to severe burns if you have a history of bone fracture, weak bones eg, osteoporosis , or low calcium intake if you drink alcohol or have a history of alcohol abuse if you will be having surgery or certain lab procedures if you take a beta-blocker eg, propranolol .

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the pharmacokinetics of propranolol hydrochloride extended-release capsules, usp, have not been investigated in patients with hepatic insufficiency.


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