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the metabolism of propranolol is reduced by co-administration of quinidine, leading to a two-three fold increased blood concentration and greater degrees of clinical beta-blockade.
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this result would be compatible with the regression observed in ih, and it would suggest that propranolol could delay the proliferation of hemangioblastomas in vhl patients.
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the pharmacokinetics of propranolol hydrochloride extended-release capsules, usp, have not been investigated in patients with hepatic insufficiency.
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