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all adverse events that were reported by greater than or equal to 2 of patients who received the recommended daily dose of clarinex reditabs tablets 5 mg once daily , and that were more common with clarinex reditabs tablets than placebo, are listed in table 1.
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hepatically impaired clarinex reditabs pharmacokinetics were characterized following a single oral dose in patients with mild n 4 , moderate n 4 , and severe n 4 hepatic impairment as defined by the child-pugh classification of hepatic function and 8 subjects with normal hepatic function.
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lethality occurred in rats at oral doses of 250 mg kg or greater estimated clarinex-d and clarinex-d metabolite exposures were approximately 120 times the auc in humans at the recommended daily oral dose .
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in 3 separate controlled, parallel group clinical pharmacology studies, clarinex-d at the clinical dose of 5 mg has been co-administered with azithromycin 500 mg followed by 250 mg once daily for 4 days n 18 or with fluoxetine 20 mg once daily for 7 days after a 23-day pretreatment period with fluoxetine n 18 or with cimetidine 600 mg every 12 hours for 14 days n 18 under steady state conditions to healthy male and female subjects.
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clarinex-d extended release tablets should be administered when the antihistaminic properties of clarinex-d and the nasal decongestant properties of pseudoephedrine are desired.
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