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advise patients and caregivers that the patient using bupropion for smoking cessation should stop taking bupropion and contact a healthcare provider immediately if agitation, hostility, depressed mood, or changes in thinking or behavior that are not typical for the patient are observed, or if the patient develops suicidal ideation or suicidal behavior.

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the second study showed no statistically significant differences in the pharmacokinetics of bupropion and its active metabolites in 9 patients with mild to moderate hepatic cirrhosis compared to 8 healthy volunteers.

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the most common side effects of bupropion are change in appetite, dizziness, constipation, drowsiness, dry mouth, headache, sweating, nausea, nervousness, restlessness, taste changes, trouble sleeping, vomiting, and weight changes.

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