Coadministration of dyazide triamterene hydrochlorothiazide resulted in a higher plasma amantadine concentration in a 61-year-old man receiving amantadine hydrochloride 100 mg tid for parkinson s disease.
In the treatment of parkinson s disease, amantadine is less effective than levodopa, – -3- 3,4-dihydroxyphenyl -l-alanine, and its efficacy in comparison with the anticholinergic antiparkinson drugs has not yet been established.
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Zanamivir or oseltamivir also can be used for treatment of influenza a infection; however, efficacy of these neuraminidase-inhibitor antivirals relative to amantadine or rimantadine remains to be more fully evaluated.
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as any other medication, amantadine can cause certain side effects.