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if vemurafenib and another drug, such as olanzapine, that is associated with a possible risk for qt prolongation and torsade de pointes tdp must be coadministered, ecg monitoring is recommended; closely monitor the patient for qt interval prolongation.
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the pharmacokinetic characteristics of olanzapine were similar in patients with severe renal impairment and normal subjects, indicating that dosage adjustment based upon the degree of renal impairment is not required.
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